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Manga Studio is great for a vectored like look without actually having to vector anything. Big downside is its super tedious, boring and repetitive. That and MS lacks a TON in different layer types so lighting either has to be done straight in coloring or in another program.
Sorta why I’ve been leaning on SAI more lately. Adore its brushes. Liking Photoshop CS6 a lot more since I started leaning more of what its capable of.